An Expert Roundtable Discussion on Mitochondrial Toxicity
Makaleler > Tam Makale · 2019
Yazarlar: Mathieu Vinken, Yvonne Will, Kendall Wallace, Philip Hewitt, Hartmut Jaeschke, Hilmi ORHAN
Applied In Vitro Toxicology, Uluslararası, Scopus, 2019, cilt 5, ss 167-172
DOI: 10.1089/aivt.2019.29022.rtl
Özet
Mitochondria play critical roles in all cell types.They are involved in processes such as calcium storage and signalling, cell proliferation, apoptosis, steroid synthesis, immunity, energy storage and production.Inherent to these vital functions, mitochondria represent frequent targets for toxicity and disease.A plethora of toxicants are indeed known to affect mitochondria.Furthermore, more than 200 clinical pathologies have been associated with impairment of mitochondrial functionality, including cancer, inflammatory disorders, neurodegenerative diseases and diabetes.Both structural defects and functional deterioration may underlie mitotochondrial toxicity, and as such form key events in various adverse outcome pathways.Not surprisingly, mitochondrial toxicity is increasingly gaining attention by toxicologists and therefore was the central theme of this expert roundtable discussion.