Fused Pyridine Derivatives: Synthesis and Biological Activities
Book chapter > Chapter Other Book · 2022
Authors: Gülşah BAYRAKTAR
Exploring Chemistry with Pyridine Derivatives, Chapter Other Book, IntechOpen, B, International, 2022, pp 1-6, England, london
DOI: 10.5772/intechopen.107537
Summary
Five-membered heteroaromatic ring fused pyridine derivatives are of increasing interest in drug design and medicinal chemistry. The structural similarity of many drugs (especially antiviral and anticancer ones) with DNA bases such as adenine and guanine is a key factor to explain their effectiveness. Apart from these, it is also found in the structures of substances with antituberculosis, antibacterial, antifungal, anti-inflammatory, and antimalarial activities. Another advantage of this group of compounds is their positive contribution to solubility, polarity, lipophilicity, and hydrogen bonding capacity properties of the compounds they are incorporated into. In this chapter, various bioactivities of fused pyridine derivatives will be categorized and summarized.