Deuterium-Labeled Precursor Feeding Reveals a New pABA-Containing Meroterpenoid from the Mango Pathogen Xanthomonas citri pv. mangiferaeindicae
Makaleler > Tam Makale · 2016
Yazarlar: Hesham Saleh, Daniel Petras, Andi Mainz, Dennis Kerwat, Ayse Nalbantsoy, Yalcin Erzurumlu, Roderich D. Süssmuth
Journal of Natural Products, Uluslararası, 2016, cilt 79, ss 1532-1537
DOI: 10.1021/acs.jnatprod.5b01049
Özet
A new para-aminobenzoic-acid-containing natural product from the mango pathogenic organism Xanthomonas citri pv. mangiferaeindicae is described. By means of stable isotope precursor feeding combined with nontargeted LC-MS/MS, the generated spectra were clustered and visualized in a molecular network. This led to the identification of a new member of the meroterpenoids, termed xanthomonic acid, which is composed of an isoprenylated para-aminobenzoic acid. In vitro cytotoxicity assays demonstrated activity of xanthomonic acid against several human cancer cell lines by induction of autophagy.