Tadalafil attenuates ischemic damage as well as reperfusion injury in the rat ovary
Makaleler > Tam Makale · 2020
Yazarlar: Çağdaş ŞAHİN, Nuri YILDIRIM, İsmet HORTU, Ali AKDEMİR, Serdar ÖZŞENER, GÜRKAN YİĞİTTÜRK, OYTUN ERBAŞ
Journal of the Turkish-German Gynecological Association, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Scopus, 2020, cilt 21, ss 35-40
Özet
Objective: Tadalafil is a selective phosphodiesterase type-5 inhibitor with a long half-life. It has a dual function in ischaemic and re-perfused tissues, i.e. vasodilatation and anti-oxidant effects. These features of tadalafil distinguish it from other anti-oxidants. We investigated the dual effect of tadalafil on ischaemia and reperfusion injury in the rat ovary.