0093 NREM Sleep Oscillations Are Altered in Young Adults with Heightened Trait Anxiety
Bildiriler > Özet Bildiri
Yazarlar: Hazal Arpaci, Nandita Banik, Pinar Kurdoglu Ersoy, Ciara Harrington, Aycan KAPUCU, Bengi Baran
SLEEP, , , Uluslararası, Özet Bildiri, Wos, cilt 48, ss A42-A42
DOI: 10.1093/sleep/zsaf090.0093
Özet
Abstract Introduction NREM oscillations play a critical role in memory consolidation, yet their role in sleep-dependent processing of affect and anxiety symptoms remains poorly understood. The present study examines the links between NREM oscillations, emotional memory, anxiety symptoms, and negative affect and investigates whether NREM oscillations are altered in individuals with elevated trait anxiety. Methods Forty-two non-help-seeking young adults (M = 19.3, SD = 1.8 years; 77% female), with high (n = 26) vs moderate-to-low (n = 16) levels of trait anxiety symptoms were monitored during a 2 hr mid-day nap opportunity. Sleep-dependent consolidation of emotional memory was tested during this interval. Upon awakening, participants completed the State-Trait Anxiety Inventory (STAI) and Positive and Negative Affect Schedule (PANAS). Sleep spindles and slow oscillations (SO) during N2 and N3 sleep were characterized with automated detectors. Results In the entire sample, increased SO activity was associated with reduced negative affect (tsum=-17.41, pcorrected=.045, 7 electrodes) and state anxiety (tsum=-18.74, pcorrected=.046, 7 electrodes), while spindle activity correlated with higher levels of negative affect (tsum=31.57, pcorrected=.02, 13 electrodes) and state anxiety (tsum=31.23, pcorrected=.03, 13 electrodes). The High Anxiety group exhibited reduced SO activity (tsum=-30.29, pcorrected =.04, 6 electrodes) and delta power (tsum=-49.31, pcorrected=.04, 21 electrodes), with no differences in sleep architecture. No group differences were observed in sleep-dependent memory consolidation. Conclusion We demonstrated that SO activity is altered in young adults with heightened trait anxiety and is associated with reduced anxiety and negative affect in the entire sample, identifying a putative anxiolytic function. These findings suggest that NREM oscillations may be a novel target for interventions aimed at reducing anxiety. Support (if any) This work was supported by the NIMH grant K01MH114012 to Bengi Baran. Hazal Arpaci is supported by NIH Predoctoral Training Grants T32GM149386 and T32GM108540.