Absence of apolipoprotein B-3500 mutation in Turkish patients with coronary and cerebrovascular atherosclerosis
Makaleler > Tam Makale · 2008
Yazarlar: Fatma Zuhal EROĞLU, Nur SELVİ GÜNEL, Buket KOSOVA, Çığır BİRAY AVCI, Emire KUMRAL, Nejat TOPÇUOĞLU, Latife Meral KAYIKÇIOĞLU
ANADOLU KARDIYOLOJI DERGISI-THE ANATOLIAN JOURNAL OF CARDIOLOGY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2008, cilt 8, ss 7-9
Özet
Objective: The arginine-to-glutamine change at codon 3500 of the apolipoprotein B-100 (apo B) is a well-known genetic cause of hypercholesterolemia. Since increased cholesterol levels lead to atherosclerosis, identification of the carries of the apo B-3500 mutation is an important step in the risk stratification of individuals and families with hypercholesterolemia. The prevalence of this mutation in Turkish population is not well known. We aimed to investigate the frequency of apo B-100 mutations (codon 3500) C9774T (Arg 3500 -> Trp) and G9775A (Arg 3500 -> Gln) in patients with atherosclerosis in comparison with healthy subjects.