Anti-Trichomonas vaginalis activities of some Lamiaceae plants

Makaleler > Tam Makale · 2022

Yazarlar: Burcu SÜMER TÜZÜN, Tuğçe FAFAL, Evren Tileklioğlu, Hatice Ertabaklar, Bijen KIVÇAK

Journal of Research in Pharmacy, ESCI İndekslerine Giren Dergi, Uluslararası, Emerging Sources Citation Index (ESCI), 2022, cilt 26, ss 1789-1795

DOI: 10.29228/jrp.269

Özet

<p>Trichomoniasis&nbsp;is&nbsp;a&nbsp;sexually&nbsp;transmitted&nbsp;infection&nbsp;caused&nbsp;by&nbsp;the&nbsp;Trichomonas&nbsp;vaginalis,&nbsp;non-viral&nbsp;protozoan,&nbsp;affecting&nbsp;the&nbsp;world.&nbsp;Metronidazole&nbsp;is&nbsp;one&nbsp;of&nbsp;the&nbsp;effective&nbsp;treatments&nbsp;approved&nbsp;by&nbsp;the&nbsp;FDA.&nbsp;Natural&nbsp;alternative&nbsp;approaches&nbsp;are&nbsp;required&nbsp;due&nbsp;to&nbsp;developed&nbsp;of&nbsp;resistance&nbsp;and&nbsp;drug&nbsp;intolerance&nbsp;in&nbsp;long-term&nbsp;treatment.&nbsp;The&nbsp;Lamiaceae,&nbsp;with&nbsp;250&nbsp;genera&nbsp;and&nbsp;3000&nbsp;species,&nbsp;are&nbsp;one&nbsp;of&nbsp;the&nbsp;largest&nbsp;family&nbsp;based&nbsp;on&nbsp;the&nbsp;taxon&nbsp;numbers.&nbsp;Thymus,&nbsp;Salvia,&nbsp;and&nbsp;Phlomis&nbsp;are&nbsp;also&nbsp;the&nbsp;largest&nbsp;genus&nbsp;of&nbsp;the&nbsp;family.&nbsp;The&nbsp;most&nbsp;distinctive&nbsp;feature&nbsp;of&nbsp;the&nbsp;species&nbsp;is&nbsp;active&nbsp;compounds&nbsp;of&nbsp;antiprotozoal&nbsp;activities.&nbsp;In&nbsp;present&nbsp;study&nbsp;Phlomis&nbsp;armeniaca&nbsp;Willd.,&nbsp;Phlomis&nbsp;pungens&nbsp;Willd.&nbsp;var.&nbsp;pungens,&nbsp;Phlomis&nbsp;sieheana&nbsp;Rech.&nbsp;Fil.,&nbsp;Thymus&nbsp;haussknechtii&nbsp;Velen.,&nbsp;Thymus&nbsp;kotschyanus&nbsp;Boiss.&nbsp;&amp;&nbsp;Hohen.&nbsp;var.&nbsp;kotschyanus,&nbsp;Stachys&nbsp;lavandulifolia&nbsp;Vahl&nbsp;subsp.&nbsp;lavandulifolia&nbsp;and&nbsp;Salvia&nbsp;verticillata&nbsp;L.&nbsp;subsp.&nbsp;verticillata&nbsp;L.&nbsp;had&nbsp;investigated&nbsp;anti-Trichomonas&nbsp;vaginalis&nbsp;activity.&nbsp;Results&nbsp;indicated&nbsp;that&nbsp;Thymus&nbsp;haussknetchtii&nbsp;was&nbsp;found&nbsp;anti-trichomonal&nbsp;activity&nbsp;in&nbsp;250&nbsp;and&nbsp;125&nbsp;μg/ml&nbsp;concentrations&nbsp;at&nbsp;the&nbsp;end&nbsp;of&nbsp;16&nbsp;hours.&nbsp;The&nbsp;inhibition&nbsp;of&nbsp;Salvia&nbsp;verticillata&nbsp;subsp.&nbsp;verticillata&nbsp;and&nbsp;Phlomis&nbsp;sieheana.&nbsp;were&nbsp;started&nbsp;after&nbsp;24&nbsp;hours,&nbsp;and&nbsp;anti-trichomonal&nbsp;activity&nbsp;was&nbsp;detected&nbsp;70%&nbsp;and&nbsp;90%&nbsp;at&nbsp;the&nbsp;end&nbsp;of&nbsp;48&nbsp;hours,&nbsp;respectively.</p>

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