Investigation of Acquired Von Willebrand Syndrome in Children with Hypothyroidism: Reversal after Treatment with Thyroxine
Makaleler > Tam Makale · 2010
Yazarlar: Özgür Olukman, Ülkü Şahin, Tülay Kavaklı, Kaan Kavaklı
Journal of Pediatric Endocrinology and Metabolism, Uluslararası, Wos, 2010, cilt 23
Özet
Background : Acquired von Willebrand Syndrome (AvWS) is a rare bleeding disorder associated with various underlying conditions. Many case reports have been published so far on bleeding tendency in hypothyroidism resembling AvWS. Objective : This study was designed to define the relationship between hypothyroidism and AvWS and to investigate the effects of L-thyroxine treatment. Subjects : Twenty four hypothyroid patients were included in the study. Nineteen patients were evaluated during treatment, 5 patients were evaluated before hormone replacement. Methods : Complete coagulation screening tests including levels of von Willebrand Factor antigen (vWF:Ag) and functional activity (vWF:RCo) were measured by thrombocyte aggregometer. Results : We demonstrated low vWF:Ag and vWF:RCo in 13 patients. Two of the 13 patients were diagnosed as AvWS, while another 2 patients were diagnosed as hereditary vWD Type 1. The remaining patients are still being followed-up. Conclusion : We would like to attract the attention of paediatricians to the possibility of bleeding due to decreased activity of vWF in hypothyroid children.