The effect of adjunctive low-dose doxycycline therapy on clinical parameters and gingival crevicular fluid matrix metalloproteinase-8 levels in chronic periodontitis
Articles > Article · 2004
Authors: Gülnur EMİNGİL, FATMA GÜL ATİLLA, T SORSA, H LUOTO, LEVENT KIRILMAZ, H BAYLAS
JOURNAL OF PERIODONTOLOGY, Journal Indexed in SCI Expanded, International, 2004, vol 75, pp 106-115
DOI: 10.1902/jop.2004.75.1.106
Summary
Background: Low-dose doxycycline (LDD) is recognized to have non-antimicrobial properties that can therapeutically modulate the host response. The aim of the present randomized, double-blind, placebo-controlled, parallel-arm study was to examine the effectiveness of LDD in combination with non-surgical periodontal therapy, compared to non-surgical periodontal therapy alone, on gingival crevicular fluid (GCF) matrix metalloproteinase-8 (MMP-8) levels and clinical parameters over a 12-month period in patients with chronic periodontitis.