Schiff Base–platinum and ruthenium complexes and anti-Alzheimer properties
Makaleler > Tam Makale · 2024
Yazarlar: Salih GÜNNAZ, Esma Yildiz, Ayça Tunçel Oral, Fatma Yurt, Kadriye Arzum ERDEM GÜRSAN, Sevil İRİŞLİ
JOURNAL OF INORGANIC BIOCHEMISTRY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Scopus, 2024, cilt 264, ss 112790-112790
DOI: 10.1016/j.jinorgbio.2024.112790
Özet
This study investigates the effects of Pt and Ru complexes containing a Schiff base with a diimine structure on Alzheimer's disease. The Schiff base (N1E,N2E)-N1,N2-bis(isoquinolin-4-ylmethylene)benzene-1,2-diamine (I) and the novel Pt(II) and Ru(II) complexes (Ia and Ib) were synthesized and characterized using FTIR, NMR (1H, 13C), mass spectrometry, and elemental analyses. Their ability to inhibit amyloid beta (Aβ1–42) aggregation was determined in vitro using the SH-SY5Y cell line. Fluorescence spectroscopy investigated the early aggregation kinetics and dose-dependent characteristics of Aβ1–42 with the complexes. Transmission electron microscopy confirmed the results. Matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI–TOF MS) and 1H NMR spectroscopy examined the interaction with Aβ1–16. Electrochemical analysis using square wave voltammetry monitored the interaction with Aβ1–42. The synthesized complexes were active in inhibiting amyloid aggregation at a low molar ratio.