The AHI-ODI difference – what can this parameter tell us?
Bildiriler > Özet Bildiri
Yazarlar: Ludger Grote, Ding Zou, Sebastien Bailly, Elisa Perger, Özen KAÇMAZ BAŞOĞLU, Dries Testelmans, Francesco Fanfulla, Pawel Sliwinski, Thomas Penzel, Johan Verbraecken, Richard Staats, Athanasia Pataka, Jan Hedner, The Esada Collaborative Network
Clinical and epidemiological respiratory sleep medicine, , , Uluslararası, Özet Bildiri, ss PA5657-PA5657
DOI: 10.1183/13993003.congress-2025.pa5657
Özet
Introduction: Apnea Hypopnea Index (AHI) and Oxygen Desaturation Index (ODI) are considered traditional severity measures used in Obstructive Sleep Apnea (OSA). AHI and ODI frequently overlap but both are used in the daily routine to reflect different components of OSA pathophysiology. A lower AHI-ODI difference signifies a relatively stronger hypoxic component. However, the AHI-ODI difference has not systematically been applied in clinical sleep medicine. The aim of the current study was to understand the significance of this parameter in the clinical and research context. Method: Data from 22026 patients in the European Sleep Apnea Database (ESADA, an ERS CRC) (mean age 54±14 years, BMI 32±7 kg/m2, 70% males) undergoing sleep studies (polygraphy or polysomnography) was used to calculate the individual AHI-ODI difference. Predictors of AHI-ODI differences including anthropometrics, comorbidities and type of sleep test were assessed. Results: Age (β-coefficient 0.23), mean overnight saturation (0.61) and male gender (1.09) significantly enhanced whereas BMI (-0.11, p<0.001), comorbid COPD (-1.02) and use of polygraphy (-2.57) all independently reduced the AHI-ODI difference in multivariate analysis (all p<0.001). The AHI-ODI difference varied considerably between centres but was not influenced by cardiovascular comorbidity or daytime sleepiness. Conclusion: A conventional metric based on the AHI to ODI difference was found to reflect hypoxia-related conditions in sleep medicine diagnostics. This simple, but novel, metric may be useful in clinical decisions when seeking information on hypoxic burden in patients with OSA. The independent between-centre variability in AHI-ODI difference suggests a variation in scoring practice.