Design, Synthesis, and Biological Evaluation of Methoxy-Substituted Chalcones and Gypsogenin-Based Hybrids as Anticancer and Antimicrobial Agents

Makaleler > Tam Makale · 2026

Yazarlar: Nafia Gökçe Ulusoy, Safiye EMİRDAĞ, Nuran Kahriman, Fatma Demir, Vildan Serdaroğlu, Nurettin Yaylı, Burçin Türkmenoğlu

ACS Omega, Uluslararası, Wos, 2026, cilt 11, ss 25537-25551

DOI: 10.1021/acsomega.5c13679

Özet

) were performed to explore potential interactions with key cancer-related targets. Overall, the results highlight the chalcone scaffold as the main contributor to biological activity in this series and demonstrate that hybridization with gypsogenin did not enhance the cytotoxic potency.

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