Relationship Between IL1 beta-511C >T and ILRN VNTR Polymorphisms and Keratoconus
Makaleler > Tam Makale · 2014
Yazarlar: Melis PALAMAR ONAY, HÜSEYİN ONAY, Taha Resid Ozdemir, Esra ARSLAN, SAİT EĞRİLMEZ, Feriştah Ferda ÖZKINAY, AYŞE YAĞCI
CORNEA, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2014, cilt 33, ss 145-147
DOI: 10.1097/ico.0000000000000027
Özet
Purpose:The aim of this study was to evaluate the relationship between keratoconus (KC) and interleukin-1 (IL1 ) (-511C>T) and interleukin-1 receptor antagonist (IL1RN) variable number of tandem repeat (VNTR) polymorphisms that are potentially associated in their genetic susceptibility to KC.Methods:A total of 121 patients with KC and 121 healthy individuals were enrolled. Blood samples with ethylenediamine tetraacetic acid were obtained, and IL1 (-511C>T) (rs16944) (polymerase chain reaction-restriction fragment length polymorphism method) and IL1RN VNTR polymorphisms (rs2234663) (polymerase chain reaction and agarose gel imaging) were investigated.Results:Genotype and allele distribution for IL1 (-511C>T) and IL1RN VNTR polymorphisms among the KC and healthy groups showed no difference (for all; P > 0.05).Conclusions:Because the genotype and allele frequency of both polymorphisms are identical, it is most likely that IL1-511C>T and IL1RN VNTR polymorphisms do not play a role in the development of KC in the Turkish population.