Nerve growth factor or IL-3 induces more IL-13 production from basophils of allergic subjects than from basophils of nonallergic subjects
Makaleler > Tam Makale · 2001
Yazarlar: Aytül Zerrin SİN, EM Roche, A Togias, LM Lichtenstein, JT Schroeder
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2001, cilt 108, ss 387-393
Özet
Background: Studies show that nerve growth factor (NGF) exhibits immunomodulatory activity. This neurotrophin is found at high levels in the serum of asthmatic individuals, is released during allergic reactions, and is reported to augment in vitro histamine and leukotriene C4 release by human basophils.