Subacute THYROiditis Related to SARS-CoV-2 VAccine and Covid-19 (THYROVAC Study): A Multicenter Nationwide Study
Makaleler > Tam Makale · 2023
Yazarlar: ADNAN BATMAN, DİLEK YAZICI, OĞUZ DİKBAŞ, KEMAL AĞBAHT, EMRE SEDAR SAYGILI, İBRAHİM DEMİRCİ, NURBANU BURSA, GÖRKEM AYAS, CÜNEYD ANIL, FAZIL MUSTAFA CESUR, FATMA NUR KORKMAZ, ADİLE BEGÜM BAHÇECİOĞLU MUTLU, DEMET ÇORAPÇIOĞLU, MURAT FAİK ERDOĞAN, HAYRİ BOSTAN, MURAT ÇALAPKULU, SEMA HEPŞEN, BEKİR UÇAN, ERMAN ÇAKAL, Bagdagul Yuksel Guler, CEM HAYMANA, SÜLEYMAN HİLMİ İPEKÇİ, SELAMİ AYDIN, HAVVA SEZER, SEÇİL ÖZIŞIK, OĞUZHAN DEYNELİ, MAHMUT FARUK ALAGÖL, REFİK TANAKOL, MUSTAFA EROĞLU, ÜMMÜ MUTLU, HÜLYA HACİŞAHİNOĞULLARI, AYŞE KUBAT ÜZÜM, CANAN DEMİR, GÖNÜL KOÇ, SEVDE NUR FIRAT, TÜLAY OMMA, NURCAN İNCE, ŞEFİKA BURÇAK POLAT, OYA TOPALOĞLU, CEVDET AYDIN, BEKİR ÇAKIR, ÇİĞDEM TURA BAHADIR, MEHMET GÜVEN, MEHMET SÖZEN, ALEV SELEK, ZEYNEP CANTÜRK, BERRİN ÇETİNARSLAN, MUSTAFA AYDEMİR, IŞILAY TAŞKALDIRAN, YUSUF BOZKUŞ, ÖZLEM TURHAN İYİDİR, FİLİZ EKŞİ HAYDARDEDEOĞLU, SEDA EREM BASMAZ, MEHMET ÇAĞRI ÜNAL, TEVFİK DEMİR, AYTEN OĞUZ, ÖZLEM ÇELİK, MERVE YILMAZ, AYKUT ÇİMŞİR, SERDAR KAYIHAN, ZİYNET ALPHAN ÜÇ, SAKİN TEKİN, ÖMERCAN TOPALOĞLU, BAŞAK ÖZGEN SAYDAM, YASEMİN AYDOĞAN ÜNSAL, ÖZGE ÖZER, GÖKNUR YORULMAZ, KADER UĞUR, SEZİN DOĞAN ÇAKIR, MEHMET AŞIK, MUSTAFA ÜNÜBOL, SELİN GENÇ, BURAK ANDAÇ, MİNE OKUR, ÖZLEM DOĞAN, ERSEN KARAKILIÇ, Gökçen ÜNAL KOCABAŞ, CEM ONUR KIRAÇ, GÜVEN BARIŞ CANSU, MELİHA MELİN UYGUR, ZAFER PEKKOLAY, SADETTİN ÖZTÜRK, AŞKIN GÜNGÜNEŞ, EREN GÜRKAN, LEZZAN KESKİN, KENAN ÇAĞLAYAN, YASEMİN EMÜR GÜNAY, EREN İMRE, SELÇUK YUSUF ŞENER, AHMET TOYGAR KALKAN, DENİZ ENGİN GÖK, MUSTAFA ŞAHİN
The Journal of Clinical Endocrinology & Metabolism, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Scopus, 2023, cilt 108, ss e1013-e1026
Özet
CONTEXT: The aims of the study are to compare characteristics of subacute thyroiditis (SAT) related to different etiologies, and to identify predictors of recurrence of SAT and incident hypothyroidism. METHODS: This nationwide, multicenter, retrospective cohort study included 53 endocrinology centers in Turkey. The study participants were divided into either COVID-19-related SAT (Cov-SAT), SARS-CoV-2 vaccine-related SAT (Vac-SAT), or control SAT (Cont-SAT) groups. RESULTS: Of the 811 patients, 258 (31.8%) were included in the Vac-SAT group, 98 (12.1%) in the Cov-SAT group, and 455 (56.1%) in the Cont-SAT group. No difference was found between the groups with regard to laboratory and imaging findings. SAT etiology was not an independent predictor of recurrence or hypothyroidism. In the entire cohort, steroid therapy requirement and younger age were statistically significant predictors for SAT recurrence. C-reactive protein measured during SAT onset, female sex, absence of antithyroid peroxidase (TPO) positivity, and absence of steroid therapy were statistically significant predictors of incident (early) hypothyroidism, irrespective of SAT etiology. On the other hand, probable predictors of established hypothyroidism differed from that of incident hypothyroidism. CONCLUSION: Since there is no difference in terms of follow-up parameters and outcomes, COVID-19- and SARS-CoV-2 vaccine-related SAT can be treated and followed up like classic SATs. Recurrence was determined by younger age and steroid therapy requirement. Steroid therapy independently predicts incident hypothyroidism that may sometimes be transient in overall SAT and is also associated with a lower risk of established hypothyroidism.