Experimental Animal Models Mimicking Sepsis in Humans
Kitapta bölümler > Diğer · 2024
Yazarlar: Ebru Eroğlu, Aylin GÖKHAN
3D Imaging, Neuroscience And Sepsis Research: Modern Methods And Technological Advances, Diğer, BZT TURAN PUBLISHING HOUSE, B, Uluslararası, 2024, ss 127-162, Türkiye, İstanbul
Özet
<p>Sepsis, characterized by a severe, systemic response to infection, remains a critical challenge in medical research due to its high mortality rates and complex pathophysiology. Experimental animal models are indispensable tools in sepsis research, providing valuable insights into disease mechanisms and potential therapeutic strategies. Traditional models have utilized toxin injection, disruption of tissue integrity, and pathogen injection to replicate various aspects of sepsis. Recent advancements in sepsis modeling have focused on refining these approaches to better replicate the polymicrobial nature of human sepsis. Innovations such as combination models integrating both toxin and live bacterial challenges have been developed to create more realistic sepsis environments. Furthermore, genetically modified animal models have provided deeper insights into species-specific responses and the genetic basis of sepsis susceptibility. These models have been instrumental in identifying critical genetic factors that influence sepsis outcomes and discovering potential therapeutic targets. As the field continues to evolve, integrating advanced imaging, molecular techniques, and refined modeling approaches holds promise for enhancing the clinical relevance of sepsis research and improving patient outcomes.</p>