Calcineurin inhibitor-based and free regimens have distinct gene expression patterns in subclinical graft fibrosis
Articles > Article · 2011
Authors: Hüseyin TÖZ, Sait ŞEN, Handan AK, Mümtaz YILMAZ, Ender HUR, Cuneyt HOŞCOŞKUN, Mehmet ÖZKAHYA, Hikmet Hakan AYDIN
ANNALS OF TRANSPLANTATION, Journal Indexed in SCI Expanded, International, 2011, vol 16, pp 76-87
DOI: 10.12659/aot.881869
Summary
Background: Chronic nephrotoxic effects of calcineurin inhibitors may be responsible for late allograft dysfunction and reduced allograft half-life. Mammalian target of rapamycin inhibitors (mTOR-i's), a newer class of immunosuppressant, do not have the chronic nephrotoxic effects shown with calcineurin inhibitors (CNI). Whether these drug classes have distinct features at the molecular level is not clear.