Calcineurin inhibitor-based and free regimens have distinct gene expression patterns in subclinical graft fibrosis
Makaleler > Tam Makale · 2011
Yazarlar: Hüseyin TÖZ, Sait ŞEN, Handan AK, Mümtaz YILMAZ, Ender HUR, Cuneyt HOŞCOŞKUN, Mehmet ÖZKAHYA, Hikmet Hakan AYDIN
ANNALS OF TRANSPLANTATION, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2011, cilt 16, ss 76-87
DOI: 10.12659/aot.881869
Özet
Background: Chronic nephrotoxic effects of calcineurin inhibitors may be responsible for late allograft dysfunction and reduced allograft half-life. Mammalian target of rapamycin inhibitors (mTOR-i's), a newer class of immunosuppressant, do not have the chronic nephrotoxic effects shown with calcineurin inhibitors (CNI). Whether these drug classes have distinct features at the molecular level is not clear.