Contribution to the phytochemical study of Paronychia chionaea Boiss
Makaleler > Tam Makale · 2008
Yazarlar: S Avunduk, MA Lacaille-Dubois, T Miyamoto, ÖA Çalışkan
Planta Medica, Uluslararası, Wos, 2008, cilt 74
Özet
Paronychia , a genus of the family Illecebraceae, is represented by 28 species in the flora of Turkey . P. chionaea Boiss. is an endemic plant, which is a prostrate caespitose herb, often woody at the base [1]. Although there are no reports of the medicinal uses of P. chionaea , P. argentea Lam. has been used in Palestinian and Jordanian traditional medicine for its hypoglycemic activity and to treat disorders of the urinary system [2,3]. Our previous phytochemical research on P. chionaea Boiss has resulted in the isolation and characterization of four gypsogenic acid-type saponins [4]. In continuation of our phytochemical investigation on this plant, three further secondary metabolites were isolated from its roots by using various solid/liquid chromatographic techniques on reversed phase Silica gel RP-18, Sephadex LH 20 and polyamide. The structure was established mainly by means of 1D and 2D NMR experiments ( 1 H-NMR, 13 NMR/DEPT, 1 H- 1 H COSY, NOESY, HSQC, HMBC) and by FABMS. One of them belonging to the flavonoid structural type has been elucidated as 6-C-[α-L-arabinopyranosyl-(1→2)-β-D-glucopyranosyl]-7-O-[β-D-glucopyranosyl]-luteolin 3'-methyl ether. To our knowledge, the occcurence of this flavonoid had not been previously reported. The structural investigation of the two other compounds is still in progress. References: 1. Davis, P. H. (1965) Flora of Turkey and the East Aegean Islands; Edinburgh University Press: Edinburgh,; Vol. 2, p 258. 2. Ali-Shtayeh, M.S. et al. (2000)J. Ethnopharmacol. 73:221–232. 3. Hamdan, I. et al. (2004)J. Ethnopharmacol. 93:117–121. 4. Avunduk, S. et al. (2007)J. Nat. Prod. 70:1830–1833.