First Report of Candidemia Clonal Outbreak Caused by Emerging Fluconazole-Resistant Candida parapsilosis Isolates Harboring Y132F and/or Y132F+K143R in Turkey
Makaleler > Tam Makale · 2020
Yazarlar: Amir Arastehfar, Farnaz Daneshnia, Süleyha HİLMİOĞLU POLAT, Wenjie Fang, Melike YAŞAR DUMAN, Furkan Polat, Dilek Yeşim METİN, Petra Rigole, Tom Coenye, Macit Ilkit, Weihua Pan, Wanqing Liao, Ferry Hagen, Markus Kostrzewa, David S. Perlin, Cornelia Lass-Flörl, Teun Boekhout
Antimicrobial Agents and Chemotherapy, Uluslararası, Wos, 2020, cilt 64
DOI: 10.1128/aac.01001-20
Özet
Clonal outbreaks of fluconazole-resistant (FLZR) Candida parapsilosis isolates have been reported in several countries. Despite its being the second leading cause of candidemia, the azole resistance mechanisms and the clonal expansion of FLZR C. parapsilosis blood isolates have not been reported in Turkey. In this study, we consecutively collected C. parapsilosis blood isolates ( n = 225) from the fifth largest hospital in Turkey (2007 to 2019), assessed their azole susceptibility pattern using CLSI M27-A3/S4, and sequenced ERG11 for all and MRR1 , TAC1 , and UPC2 for a selected number of C. parapsilosis isolates.