Multimodal Imaging of Reticular Pseudodrusen in Turkish Patients
Articles > Article · 2023
Authors: SERAP BİLGE YILDIRIM, Filiz AFRASHİ, Cumali DEĞİRMENCİ, JALE MENTEŞ, SERHAD NALÇACI, Cezmi AKKIN
Türk Oftalmoloji Dergisi, Journal Indexed in ESCI, International, TR DİZİN (ULAKBİM), 2023, vol 53, pp 275-280
DOI: 10.4274/tjo.galenos.2023.85616
Summary
<h2><strong>Abstract</strong></h2><p><strong>Objectives: </strong>To investigate the presence and prevalence of reticular pseudodrusen (RPD) in patients with age-related macular degeneration using multiple imaging modalities and to compare the sensitivity and specificity of these modalities in the detection of RPD.</p><p><strong>Materials and methods: </strong>Images from a total of 198 consecutive patients were analyzed prospectively. Color fundus photography, red-free imaging, spectral domain optical coherence tomography (SD-OCT), infrared and blue reflectance (BR) imaging, fundus autofluorescence (FAF), enhanced-depth imaging OCT (EDI-OCT), fundus fluorescein angiography (FFA) and indocyanine green angiography were performed. RPD was diagnosed in the presence of relevant findings in at least two of the imaging methods used.</p><p><strong>Results: </strong>RPD were detected in 149 eyes (37.6%). In the detection of RPD, color fundus photography, red-free photography, SD-OCT, infrared, FAF, BR, and FFA imaging had sensitivity values of 50%, 57.7%, 91.6%, 95%, 74.6%, 65.7%, and 28.2% and specificity values of 99.6%, 100%, 98.4%, 94.6%, 100%, 99.6%, and 69.8%, respectively.</p><p><strong>Conclusion: </strong>Infrared imaging had the highest sensitivity. SD-OCT combined with infrared imaging was the most sensitive imaging technique for detecting RPD. The high specificity of FAF, red-free, and BR imaging may be useful to confirm a diagnosis of RPD.</p>