Cutaneous manifestations of primary immune deficiencies
Makaleler > Derleme · 2025
Yazarlar: Ayda ACAR, Fatma Ömür ARDENİZ
CUTANEOUS AND OCULAR TOXICOLOGY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Journal Citation Reports/Social Sciences Edition, 2025, cilt 44, ss 1-9
DOI: 10.1080/15569527.2025.2511721
Özet
PURPOSE: Primary immune deficiencies (PIDs) can present with a wide range of clinical findings. This review aims to evaluate PIDs in which cutaneous findings are common. MATERIALS AND METHODS: English literature regarding cutaneous manifestations of primary immunodeficiencies was reviewed using PubMed between January 2005 and March 2023. RESULTS: Cutaneous findings in PIDs can be broadly classified into two main groups: infectious and non-infectious. The most prevalent skin finding in PIDs is cutaneous infections (bacterial, fungal, and viral), and these infections often manifest as early-onset, recurrent, treatment-resistant, or atypical cases. Eczema is being the most frequent among non-infectious findings. Cutaneous manifestations, such as erythroderma, telangiectasia, granulomatous dermatitis, and autoimmune symptoms like alopecia and vitiligo can also occur. CONCLUSION: Cutaneous manifestations in PIDs can assist clinicians in making early diagnoses, enabling patients to receive appropriate therapy promptly.