Sustained-Release Dosage form of Phenylpropanolamine Hydrochloride (3). Application of Factorial Design
Articles > Article · 1994
Authors: F. Sevgi, M. Özyazici, T. Güneri
Journal of Microencapsulation, International, 1994, vol 11, pp 439-444
DOI: 10.3109/02652049409034261
Summary
In this study a 2(2) factorial design has been applied to the evaluation of dissolution characteristics of phenylpropranolamine hydrochloride (PPA.HCl) from tableted microcapsules. The kinetic model according to the Rosin-Rimmler-Sperling-Bennet-Weillbull (RRSBW) distribution was applied for the parametric representation of the dissolution curves. The effect of two factors; drug particle size and kind of disintegrating agent, on the dissolution rate of PPA.HCl were studied at two levels. The factorial design method proved to be useful for the examination of tableted microcapsules.