Design, synthesis and evaluation of biological activities of some new carbohydrazide and urea derivatives
Articles > Article · 2018
Authors: Fatih Tok, Recep İlhan, Selin Günal, Petek BALLAR KIRMIZIBAYRAK, Bedia Koçyiğit-kaymakçıoğlu
The Turkish Journal of Pharmaceutical Sciences, International, Scopus, 2018, vol 15, pp 304-308
DOI: 10.4274/tjps.64935
Summary
Cancer is one of the major causes of death worldwide.The development of identification and treatment are important for cancer treatment.However, effective and selective treatment methods are insufficient against some types of cancer.Scientists continue their studies to find effective molecules for cancer treatment.1,2 Compounds bearing nitrogen, sulfur, and oxygen play a significant role by forming hydrogen bonds with DNA. 3 Therefore heterocyclic compounds such as pyridine and pyrimidine showed anticancer, 4 antibacterial, 5 antifungal, 6 analgesic, and anti-inflammatory activity.7 Sorafenib, which carries a pyridine ring and urea group was confirmed by the United States Food and Drug Administration for the treatment of renal cell carcinoma in 2005.Sorafenib, which