Cytotoxicity in Astrocyte Cultures Due to pH Changes and Protection by Glutathione
Makaleler > Tam Makale · 2010
Yazarlar: Özlem YILMAZ, Dilek TAŞKIRAN
JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2010, cilt 27, ss 61-68
Özet
Background: It is well known that extracellular and intracellular pH changes have cytotoxic effects on astrocytes and neurons. In the present study, we aimed to evaluate the cytotoxic effects of acidosis on astrocyte cultures by measuring cell death and oxidative stress parameters. We also investigated the protective effects of ascorbic acid and gluthatione as antioxidants against toxicity due to pH changes in the cultures.