Decreased Anxiety-Like Behavior in a Selectively Bred High Nicotine-Preferring Rat Line
Makaleler > Tam Makale · 2024
Yazarlar: Merve Bayoglu, Meliha Öztürk, Lütfiye KANIT, Burcu BALKAN, Oğuz GÖZEN, Ersin Oğuz KOYLU, Ayşegül KESER
INTERNATIONAL JOURNAL OF NEUROSCIENCE, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2024, ss 1-11
DOI: 10.1080/00207454.2023.2279505
Özet
<p>Genetic vulnerability contributes significantly to the individual variability observed in nicotine</p><p>dependence. Selective breeding for sensitivity to a particular effect of abused drugs has produced</p><p>rodent lines useful for studying genetic vulnerability to drug addiction. Previous research showed</p><p>that anxiety-related personality traits are associated with nicotine dependence. Therefore, we</p><p>examined the differences in anxiety-like behavior between a high nicotine-preferring rat line and</p><p>their controls. At the beginning of the study, all rats, naïve to any drug, were exposed sequentially</p><p>to open field arena, marble-burying and elevated plus-maze paradigms. In the second step, all</p><p>rats received nicotine in drinking water for 7 weeks. Behavioral tests were rerun on the final 2</p><p>weeks of chronic nicotine treatment. Elevated plus-maze testings under basal condition and</p><p>during chronic nicotine treatment showed that the time spent on the open arms, preference for</p><p>being in the open arms, and the latency to enter the closed arms were higher, whereas open arm</p><p>avoidance index was lower in nicotine-preferring rats compared to the controls. In the open field</p><p>test, nicotine-preferring rats spent longer time in the central zone and excreted less fecal pellets;</p><p>they buried less marbles in the marble-burying test. These findings indicate a lower level of</p><p>anxiety-like behavior in nicotine-preferring rat line under basal conditions and during chronic</p><p>nicotine treatment. We conclude that lower anxiety level in nicotine-preferring rat line is consistent</p><p>with novelty-seeking personality type and may increase vulnerability to nicotine dependence in</p><p>this rat line.</p>