Assessment of serum bisphenol a levels in autoimmune thyroiditis: A case-control study
Makaleler > Tam Makale · 2025
Yazarlar: Gökçen ÜNAL KOCABAŞ, Murat Akşit, Ilgın YILDIRIM ŞİMŞİR, Lütfiye Füsun SAYGILI, Banu Pınar ŞARER YÜREKLİ
Ege Tıp Dergisi, Uluslararası, 2025, cilt 64, ss 15-20
DOI: 10.19161/etd.1544200
Özet
Aim: The precise mechanism underlying autoimmune thyroiditis is still unclear. The female preponderance suggests the role of estrogens in autoimmunity, and there is strong evidence about this role. Bisphenol A (BPA), a widely used endocrine disruptor, may have estrogenic effects and affect autoimmunity through estrogenic and non-estrogenic mechanisms. We aimed to determine the relationship between serum BPA levels and thyroid autoimmunity. Materials and Methods: We performed a cross-sectional case-control study involving 143 autoimmune thyroiditis patients and 95 age-matched healthy controls. Serum BPA levels were measured using ELISA method. Results: BPA levels were not significantly different between autoimmune thyroiditis and control groups. The percentage of antibody-positive patients, thyroid function, thyroid antibody levels, or BMI were not different between BPA quartiles. Also, there was no correlation between BPA levels and thyroid autoantibody levels. Conclusion: Serum BPA levels were not significantly different in autoimmune thyroiditis. Also, we could not show any relationship between BPA, thyroid function tests, and thyroid antibody levels.