Iridium(I)-Catalyzed Alkylation Reactions To Form alpha-Alkylated Ketones
Makaleler > Tam Makale · 2018
Yazarlar: Sertac GENC, SALİH GÜNNAZ, BEKİR ÇETİNKAYA, Süleyman GÜLCEMAL, Derya GÜLCEMAL
JOURNAL OF ORGANIC CHEMISTRY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2018, cilt 83, ss 2875-2881
Özet
A highly effective and green procedure for the formation of alpha-alkylated ketones has been disclosed via the reaction of primary alcohols with secondary alcohols and ketones by using [IrCl(COD)(NHC)] complexes as a catalyst. Various alpha-alkylated ketones were obtained in high yields from the alkylation of alcohol with alcohol and ketone with alcohol through a borrowing hydrogen reaction by using 0.05-0.5 mol % iridium(I) and a catalytic amount of KOH (5-10 mol %) as the base under air atmosphere and within very short reaction times.