In vitro evaluation of apoptosis with 99mTc-glucoheptonate
Makaleler > Tam Makale · 2011
Yazarlar: Gamze Kocagozoglu, Fatma YURT, Cumhur GÜNDÜZ, Musteyde Yucebas, Elif Bayrak Tabar, Aykut Ozgur, Tugce Balci
Applied Radiation and Isotopes, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2011, cilt 69, ss 955-959
DOI: 10.1016/j.apradiso.2011.03.006
Özet
Radiopharmaceuticals are useful to evaluate effectiveness of cancer treatments as well as diagnosis of diseases. Tc-99m-Glucoheptonate has high sensitivity for imaging lung cancer tissues. In this study, the potential use of Tc-99m-glucoheptonate for monitoring apoptosis related to chemotherapeutic agents is investigated in vitro using A549 lung cancer cell line. A decrease in Tc-99m-glucoheptonate uptake ratio was observed depending on the level of apoptosis. Tc-99m-glucoheptonate is found to be useful for the detection of apoptosis following treatment in A549 lung tumor cells. (C) 2011 Elsevier Ltd. All rights reserved.