Liver and Spleen Point Shear-Wave Elastography in Newly Diagnosed BCR-ABL1-Negative Myeloproliferative Neoplasms: Associations with Hematologic Parameters and Bone Marrow Fibrosis Grade - A Prospective Cross-Sectional Study
Makaleler > Tam Makale · 2026
Yazarlar: Mehmet Taha Avci, Melda Cömert, Hatice Demet Kiper Unal, Gülgün KAVUKÇU, Ayhan DÖNMEZ, Sadık TAMSEL, Mine HEKİMGİL, Nazan ÖZSAN, Suha Ozbek
Turkish Journal of Hematology, Uluslararası, Wos, 2026, cilt 43, ss 204-212
DOI: 10.4274/tjh.galenos.2026.77528
Özet
Objective: -negative myeloproliferative neoplasms (MPNs) using point shear-wave elastography (pSWE) and to explore associations with hematological parameters and bone marrow fibrosis grade. Materials and Methods: -negative MPNs, including cases of essential thrombocythemia (n=13), primary myelofibrosis (MF) (n=12), and polycythemia vera (n=8), and for 31 age- and sex-matched controls. Shear-wave velocity (Vs, m/s) was recorded as the median of ≥10 valid measurements per organ, with interquartile range/median of <30% as the reliability criterion. Correlations with blood counts and bone marrow fibrosis grade were evaluated. Receiver operating characteristic curve analysis was exploratory because of the modest sample size and limited number of high-grade fibrosis cases. Results: Hepatic Vs was higher in patients than in the control group (1.21 [1.09-1.34] vs. 0.98 [0.86-1.11] m/s; p<0.01), whereas splenic Vs was similar between the groups (3.09 [2.76-3.50] vs. 3.21 [2.91-3.44] m/s; p=0.41). Hepatic Vs correlated with leukocyte count (r=0.47; p<0.01) and bone marrow fibrosis grade (r=0.47; p<0.05). Hepatic Vs identified MF of grade 3 with an area under the curve value of 0.77; however, the proposed cut-off of ≥1.22 m/s should be interpreted as a preliminary research threshold rather than a clinically validated threshold. Conclusion: -negative MPN cohort and showed a modest association with marrow fibrosis grade and leukocyte count. Splenic stiffness was not increased in this mixed-subtype cohort. These findings support hepatic pSWE as a hypothesis-generating adjunct to baseline phenotyping but not as a replacement for bone marrow biopsy or hematological risk assessment.