Endotoxin differentially modulates the basolateral and apical sodium/proton exchangers (NHE) in enterocytes
Makaleler > Tam Makale · 2004
Yazarlar: S CETIN, J DUNKLEBARGER, J LI, P BOYLE, Mustafa Orkan ERGÜN, F QURESHI, H FORD, J UPPERMAN, S WATKINS, DJ HACKAM
SURGERY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2004, cilt 136, ss 375-383
DOI: 10.1016/j.surg.2004.05.013
Özet
Background. Maintenance of enterocyte activity during extracellular acidosis requires functional sodium/proton exchangers (NHE), which are present at both basolateral and apical surfaces. Necrotizing enterocolitis is characterized by systemic hypoperfusion, metabolic acidosis, and the apical to basolateral translocation of endotoxin (lipopolysaccharide [LPS]). We hypothesized that LPS differentially impairs NHE activity at the basolateral or apical domains of enterocytes, leading to cellular acidification, and explored the mechanisms involved.