Interaction between vitamin D insufficiency and periodontitis, GCF vitamin D and LL-37 levels in well-controlled diabetes patients with periodontitis
Makaleler > Tam Makale · 2026
Yazarlar: Hatice Oya TÜRKOĞLU, Gülnihal Eren, Şevki ÇETİNKALP, Harika Atmaca, Gül Atilla
European Oral Research, Uluslararası, Scopus, 2026, cilt 60, ss 298-304
Özet
PurposeTo determine whether low serum vitamin D levels are inversely correlated with clinical parameters and positively correlated with gingival crevicular fluid (GCF) 25(OH)D₃, 1,25(OH)₂D₃, LL-37 and tumor necrosis factor-α (TNF-α) levels in periodontitis patients with well-controlled type-2 diabetes (T2DM).Materials and MethodsTwenty-six well-controlled T2DM patients with periodontitis and Vitamin D insufficiency (Vit.D-IS group), and 15 well-controlled T2DM patients with periodontitis and Vitamin D sufficiency (Vit.D-S group) were included. Papilla bleeding index, bleeding on probing (BOP), supragingival plaque, clinical attachment level (CAL) and probing depth (PD) were evaluated. GCF total amounts of 25(OH)D, 1,25(OH)₂D₃, LL-37 and TNF-α were analyzed by ELISA. Serum 25(OH)D₃ levels were determined using liquid chromatography tandem-mass spectrometry.ResultsWhole mouth CAL and BOP scores were higher in the Vit.D-IS group than those of Vit.D-S group (P=0.038, P=0.048, respectively). Whole mouth PD and plaque values were comparable in both groups. Differences were not detected in GCF 25(OH)D₃, 1,25(OH)₂D₃, LL- 37 and TNF-α levels between Vit.D-IS and Vit.D-S groups. Serum 25(OH)D₃ levels were adversely associated with CAL and BOP scores (P=0.018, P=0.049, respectively). Also, GCF 1,25(OH)₂D₃ total amounts were positively related with GCF LL-37 total amounts (P=0.0001).ConclusionSerum 25(OH)D₃ insufficiency was related to periodontal inflammation and destruction in periodontitis patients with well-controlled T2DM. However, GCF 25(OH)D₃, 1,25(OH)₂D₃, TNF-α and LL-37 total amounts were not correlated with serum vitamin D levels. We have opinion that obtaining and maintenance of periodontal health should be included in the diabetic treatment