Understanding clinical outcomes and factors influencing mortality in intensive care unit patients with COVID‐19‐associated candidemia
Makaleler > Tam Makale · 2024
Yazarlar: Sedat Aydın, Ali Mert, Mesut Yιlmaz, Muna Al Maslamani, Bilal Ahmad Rahimi, Folusakin Ayoade, Amani El‐Kholy, M. Belitova, Buket Ertürk Şengel, S. Jalal, Aynur Albayrak, Jamayel Adnan Alatawi, Bálint Gergely Szabó, Raj Ganeshan, Emmanuel Nsutebu, Aruna Poojary, Yasemin Akkoyunlu, Sevil Alkan, Dilşah Başkol Elik, Gulden Eser‐Karlidag, Lurdes Santos, Ruxandra Moroti, Nilgün Altın, Esra Gürbüz, Tülay Ünver Ulusoy, Oğuz Reşat Sıpahi, Hülya Çaşkurlu, Aliye Esmaoğlu, Botond Lakatos, Nagwa Mostafa El‐Sayed, Andrea Marıno, Antonio Cascio, Alexandru Mihai, Irina Magdalena Dumitru, N. Pshenichnaya, Rezaul Karim Ripon, Mateja Janković Makek, Naveed Haroon Rashid, Rusmir Baljić, Cosmin Dascalu, Gülden Sincan, Yeşim Uygun-Kızmaz, Berk Madendere, Hakan Erdem
Greater South Information System, Uluslararası, 2024
DOI: 10.60692/5dypm-09043
Özet
Abstract Background During the COVID pandemic, research has shown an increase in candidemia cases following severe COVID infection and the identification of risk factors associated with candidemia. However, there is a lack of studies that specifically explore clinical outcomes and mortality rates related to candidemia after COVID infection. Objectives The aim of this international study was to evaluate the clinical outcomes and identify factors influencing mortality in patients who developed candidemia during their COVID infection. Patients/Methods This study included adult patients (18 years of age or older) admitted to the intensive care unit (ICU) and diagnosed with COVID‐associated candidemia (CAC). The research was conducted through ID‐IRI network and in collaboration with 34 medical centres across 18 countries retrospectively, spanning from the beginning of the COVID pandemic until December 2021. Results A total of 293 patients diagnosed with CAC were included. The median age of the patients was 67, and 63% of them were male. The most common Candida species detected was C. albicans . The crude 30‐day mortality rate was recorded at 62.4%. The logistic regression analysis identified several factors significantly impacting mortality, including age (odds ratio [OR] 1.04, 95% confidence interval [CI] 1.02–1.07, p < .0005), SOFA score (OR 1.307, 95% CI 1.17–1.45, p < .0005), invasive mechanical ventilation (OR 7.95, 95% CI 1.44–43.83, p < .017) and duration of mechanical ventilation (OR 0.98, 95% CI 0.96–0.99, p < .020). Conclusions By recognising these prognostic factors, medical professionals can customise their treatment approaches to offer more targeted care, leading to improved patient outcomes and higher survival rates for individuals with COVID‐associated candidemia.