Cervical vestibular evoked myogenic potential asymmetry, but not amplitude, differentiates vestibular migraine during prolonged unidirectional visual motion
Makaleler > Tam Makale · 2026
Yazarlar: Elvira Cortese, HÜSEYİN NEZİH ÖZDEMİR, Anca-Diana Grigore, Patricia Castro, Nehzat Koohi, Diego Kaski
Frontiers in Neurology, Uluslararası, Wos, 2026, cilt 17, ss 1773410-1773410
DOI: 10.3389/fneur.2026.1773410
Özet
Introduction Vestibular migraine (VM) is the leading cause of episodic vestibular complaints. It arises from altered brain states that disrupt sensory processing. A reliance on clinical history for diagnosis highlights the need for bedside biomarkers, particularly in emergency settings where misdiagnosis is common. Methods In this cross-sectional study, 30 VM patients (median-age = 40.5; 27 females) from University College London vestibular clinics and 30 age-gender matched healthy controls (median-age = 32.5; 27 females) were recruited, between May 2024 and October 2025. Cervical Vestibular Evoked Myogenic Potential (cVEMP) responses were measured before and after a Unidirectional Visual Motion Stimuli delivered via virtual reality goggles. Results Mixed linear modeling (MLM) showed no significant effects of group, condition or ear on cVEMP amplitude (all p > 0.05). MLM on asymmetry revealed a significant effect of group, F (1, 57.21) = 11.89, p = 0.001 and condition, F (1, 56.53) = 14.47, p = <0.001; but no significant group × condition interaction, F (1, 56.53) = 1.57, p = 0.215. Spearman correlations showed no association between cVEMP delta amplitude and DHI. VM patients scored higher on all symptom’s measures compared with controls (All p < 0.001). Conclusion Prolonged unidirectional visual stimulation does not significantly affect cVEMP amplitude responses in VM, limiting its value as a differential diagnostic tool. The need to further explore asymmetry and interaural/interhemispheric sensory integration in VM is underscored.