Comorbid conditions in IPF patients; their frequencies and impacts on survival
Bildiriler > Özet Bildiri · 2018
Yazarlar: AYSU SİNEM KOÇ, Nesrin MOĞULKOÇ BISHOP, Paul Bishop
Idiopathic interstitial pneumonias, Fransa, Uluslararası, Sözlü Sunum, Özet Bildiri, 2018-2018, Wos, cilt 52, ss PA2915-PA2915
DOI: 10.1183/13993003.congress-2018.pa2915
Özet
Aim: The majority of patients with IPF have comorbidities, which affect functional status, quality of life, treatment and survival. Our study aim was to analyse comorbidities in our series of 379 IPF patients. Methods: We retrospectively examined the range of comorbidites documented in our cohort of patients with IPF. These patients were seen in our interstitial lung disease clinic between May 2008 and January 2018. All had a diagnosis of IPF based on clinical assessment and high resolution CT scan; one third underwent a surgical lung biopsy. Results: Median age at diagnosis was 65.6 years. 74% of patients are male (n=281). Systemic hypertension, latent TB and diabetes mellitus were the most frequent comorbidities as shown in the table. However, the comorbidities with the greatest impact on survival were the development of lung cancer, respiratory failure and pulmonary hypertension (PH). Hazard ratios of all comorbidities are listed in the table. Conclusion: Some comorbidities have a major adverse impact on survival. IPF management requires a comprehensive approach, which includes the identification and treatment of comorbid conditions. The protective effect of obesity we have examined elsewhere. The apparent protective effect of latent TB needs to be further explored.