In-vitro activity of rifabutin against rifampicin-resistant Mycobacterium tuberculosis isolates with known rpoB mutations
Makaleler > Tam Makale · 2004
Yazarlar: Cengiz ÇAVUŞOĞLU, Y KARACA-DERICI, A BILGIC
Clinical Microbiology and Infection, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2004, cilt 10, ss 662-665
DOI: 10.1111/j.1469-0691.2004.00917.x
Özet
The relationship between resistance to rifampicin and rifabutin and genetic alterations in the rpoB gene of 41 rifampicin-resistant isolates of Mycobacterium tuberculosis was evaluated. Although 35 isolates with rifampicin MICs greater than or equal to 32 mg/L were also rifabutin-resistant, six isolates with rifampicin MICs of 2-16 mg/L were susceptible to rifabutin (MIC less than or equal to 0.5 mg/L). Mutations Asp516Val, Asp516Tyr, Leu533Pro and the double mutation Met515Ile and Leu533Pro influenced susceptibility to rifampicin, but not to rifabutin. All mutations at codons 531 and 526, except one isolate with a His526Cys mutation, correlated with resistance to both compounds.