Radiolabeling of Morphine with I-131 and Its Biodistribution in Rats
Makaleler > Tam Makale · 2010
Yazarlar: Hueseyin Enginar, Perihan ÜNAK, Fatma YURT, Fazilet Z. Biber-Mueftueler, Beyza SEYİTOĞLU, Ayfer YURT KILÇAR, Seniha YOLCULAR, Emin İlker MEDİNE, Ibrahim BULDUK
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2010, cilt 25, ss 409-416
Özet
This study was conducted to determine the possible radiopharmaceutical potential of morphin labeled with I-131. Morphine was extracted from dry capsules of the opium poppy (Papaver somniferum L.), purified by high-performance liquid chromatography, and characterized with nuclear magnetic resonance and infrared spectroscopy. The purified compound was labeled with I-131. Male Albino Wistar rats (18) were used for receptor blockage and unblockage biodistribution studies. Tissue distribution studies showed that radiolabeled morphine had higher uptake in lung, liver, small intestines, large intestines, and stomach than the other tissues. The highest uptake of radiolabeled compounds in rats' brain was found to be in the midbrain and hypothalamus. After receptor blockage with morphine, uptake of I-131-morphine decreased in the lungs, liver, kidney, testis, prostate, spinal cord, cerebellum, hippocampus, striatum, and temporal cortex with respect to receptor unblockage studies of rats. This study concludes that the labeling yield of I-131-morphine was high, high amount of I-131-morphine was found in the hypothalamus, and I-131-morphine has enough stability for diagnostic scanning.