A case of myasthenia gravis emerging after prior diagnosis of CIDP: Clinical challenges in overlapping autoimmune disorders
Articles > Article · 2025
Authors: Şeyma AYKAÇ, Abdullah Arı, Birgül Dere, Yaprak Seçil, Ayşe Nur YÜCEYAR
Ege Tıp Dergisi, International, 2025, vol 64, pp 716-720
DOI: 10.19161/etd.1736794
Summary
Chronic inflammatory demyelinating polyneuropathy (CIDP) and myasthenia gravis (MG) are distinct autoimmune neuromuscular disorders that rarely coexist. We present a 52-year-old man with stable CIDP who developed progressive lower limb weakness and facial involvement. Electrophysiological studies revealed neuromuscular junction dysfunction, and elevated acetylcholine receptor antibodies confirmed MG. Treatment with pyridostigmine, intravenous immunoglobulin, and rituximab resulted in clinical stabilization. This case shows the importance of considering overlapping autoimmune disorders in CIDP patients with new or atypical symptoms. Early recognition using electrophysiological and serological tests is important for accurate diagnosis and effective management of coexisting CIDP and MG.