Nanočestice L-glutaminske kiseline-g-polihidroksietilnoga metakrilata - Akutna i subakutna toksičnost i bioraspodjela u miševa
Makaleler > Tam Makale · 2023
Yazarlar: Buket Bakan, Fatih OLTULU, Yeliz Ylldlrlm, Altuğ YAVAŞOĞLU, Sinan AKGÖL, Nefise Ülkü KARABAY YAVAŞOĞLU
ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE AND TOXICOLOGY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2023, cilt 74, ss 207-217
DOI: 10.2478/aiht-2023-74-3768
Özet
The aim of this safety study in mice was to determine in vivo toxicity and biodistribution potential of a single and multiple doses of L-glutamic acid-g-p(HEMA) polymeric nanoparticles as a drug delivery system. The single dose did not cause any lethal effect, and its acute oral LD50 was >2.000 mg/kg body weight (bw). Multiple doses (25, 50, or 100 mg/kg bw) given over 28 days resulted in no significant differences in body and relative organ weights compared to control. These results are supported by biochemical and histological findings. Moreover, nanoparticle exposure did not result in statistically significant differences in micronucleus counts in bone marrow cells compared to control. Nanoparticle distribution was time-dependent, and they reached the organs and even bone marrow by hour 6, as established by ex vivo imaging with the IVIS® spectrum imaging system. In conclusion, L-glutamic acid-g-p(HEMA) polymeric nanoparticles appear biocompatible and have a potential use as a drug delivery system.