The effects of selective COX-2 inhibitor/celecoxib and omega-3 fatty acid on matrix metalloproteinases, TIMP-1, and laminin-5gamma2-chain immunolocalization in experimental periodontitis.
Makaleler > Tam Makale · 2008
Yazarlar: Saynur VARDAR-SENGUL, Zeki Eralp BUDUNELİ, Hatice Oya TÜRKOĞLU, Nurcan BUDUNELI, FATMA GÜL ATİLLA, Jaana WAHLGREN, Timo Sorsa, Haluk BAYLAS
JOURNAL OF PERIODONTOLOGY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2008, cilt 79, ss 1934-1941
Özet
Background: Matrix metalloproteinases (MMPs) play important roles in tissue-destruction mechanisms-associated periodontitis. MMP-8 and - 13 are the predominant collagenases that are important in the extracellular matrix degradation in periodontal tissues. MMP- 14 is a membrane-type MMP, whereas laminin-5 indicates basal membrane modification and epithelial induction. The purpose of the present study was to evaluate the effects of celecoxib and omega-3 fatty acid administration on the gingival tissue expression of MMP-8, -13, and - 14, tissue inhibitor of MMP (TIMP)- 1, and laminin (Ln) -5 gamma 2-chain in rat experimental periodontitis induced by Escherichia coli endotoxin (lipopolysaccharide [LPS]).