Serum biotinidase activity in children with chronic liver disease and its clinical significance
Articles > Article · 2002
Authors: Nefise Aysun PABUÇÇUOĞLU, Sema AYDOĞDU, MERAL BAS
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, Journal Indexed in SCI Expanded, International, 2002, vol 34, pp 59-62
DOI: 10.1097/00005176-200201000-00014
Summary
Background: Biotinidase is the enzyme responsible for liberating the vitamin biotin from biocytin and dietary protein-bound vitamin. Individuals lacking biotinidase activity become biotin deficient. Because the liver is the major source of plasma biotinidase, chronic liver diseases can lead to decreased serum biotinidase activity and biotin deficiency. The aim of this study is to determine serum biotinidase activity values in children with chronic liver disease and to investigate the relation among enzyme activity, certain liver function tests, and degree of liver damage.