Serum biotinidase activity in children with chronic liver disease and its clinical significance
Makaleler > Tam Makale · 2002
Yazarlar: Nefise Aysun PABUÇÇUOĞLU, Sema AYDOĞDU, MERAL BAS
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2002, cilt 34, ss 59-62
DOI: 10.1097/00005176-200201000-00014
Özet
Background: Biotinidase is the enzyme responsible for liberating the vitamin biotin from biocytin and dietary protein-bound vitamin. Individuals lacking biotinidase activity become biotin deficient. Because the liver is the major source of plasma biotinidase, chronic liver diseases can lead to decreased serum biotinidase activity and biotin deficiency. The aim of this study is to determine serum biotinidase activity values in children with chronic liver disease and to investigate the relation among enzyme activity, certain liver function tests, and degree of liver damage.