Design of PLGA nanofiber wound dressing enriched with Echinacea purpurea extract and in vitro characterization

Makaleler > Tam Makale · 2026

Yazarlar: Ayşe DOĞAN

Biotechstudies, Diğer Kurumların Hakemli Dergileri, Ulusal, TR Dizin (Ulakbim), 2026, cilt 35, ss 1-9

DOI: 10.38042/biotechstudies.1904228

Özet

<p>Electrospun&nbsp;nanofiber&nbsp;wound&nbsp;dressings&nbsp;potentially&nbsp;provide&nbsp;a&nbsp;highly&nbsp;suitable&nbsp;environment&nbsp;for&nbsp;healing&nbsp;compared&nbsp;to&nbsp;traditional&nbsp;wound&nbsp;dressings,&nbsp;which&nbsp;often&nbsp;fail&nbsp;to&nbsp;meet&nbsp;all&nbsp;the&nbsp;requirements&nbsp;of&nbsp;the&nbsp;wound&nbsp;healing&nbsp;process.&nbsp;This&nbsp;study&nbsp;aimed&nbsp;to&nbsp;develop&nbsp;PLGA&nbsp;nanofibers&nbsp;incorporating&nbsp;silver&nbsp;nanoparticles&nbsp;containing&nbsp;Echinacea&nbsp;extract&nbsp;for&nbsp;use&nbsp;as&nbsp;wound&nbsp;dressings,&nbsp;perform&nbsp;their&nbsp;characterization&nbsp;tests,&nbsp;and&nbsp;evaluate&nbsp;their&nbsp;wound&nbsp;healing&nbsp;efficacy&nbsp;using&nbsp;in&nbsp;vitro&nbsp;models.&nbsp;Echinacea&nbsp;silver&nbsp;nanoparticles&nbsp;were&nbsp;synthesized&nbsp;using&nbsp;a&nbsp;green&nbsp;synthesis&nbsp;method.&nbsp;PLGA,&nbsp;silver&nbsp;nanoparticle-containing&nbsp;PLGA&nbsp;(AgNP/PLGA),&nbsp;1%,&nbsp;2%,&nbsp;3%,&nbsp;and&nbsp;Echinacea&nbsp;silver&nbsp;nanoparticle-containing&nbsp;PLGA&nbsp;(Ec-AgNP/PLGA)&nbsp;nanofibers&nbsp;were&nbsp;produced&nbsp;by&nbsp;the&nbsp;electrospinning&nbsp;method.&nbsp;The&nbsp;nanofibers&nbsp;were&nbsp;characterized&nbsp;by&nbsp;SEM,&nbsp;FTIR,&nbsp;XRD,&nbsp;and&nbsp;antibacterial&nbsp;analysis&nbsp;and&nbsp;evaluated&nbsp;using&nbsp;an&nbsp;in&nbsp;vitro&nbsp;wound&nbsp;scratch&nbsp;test.&nbsp;The&nbsp;average&nbsp;zone&nbsp;diameters&nbsp;of&nbsp;Ec&nbsp;AgNP/PLGA&nbsp;nanofibers&nbsp;against&nbsp;the&nbsp;E.&nbsp;coli&nbsp;and&nbsp;S.&nbsp;aureus&nbsp;bacteria&nbsp;were&nbsp;found&nbsp;to&nbsp;be&nbsp;13.5±0.3&nbsp;mm.&nbsp;The&nbsp;antioxidant&nbsp;capacity&nbsp;analysis&nbsp;of&nbsp;the&nbsp;Echinacea&nbsp;extract&nbsp;used&nbsp;in&nbsp;the&nbsp;study&nbsp;was&nbsp;evaluated&nbsp;by&nbsp;the&nbsp;DPPH&nbsp;(2,2-diphenyl-1-picrylhydrazyl)&nbsp;method,&nbsp;and&nbsp;the&nbsp;percentage&nbsp;of&nbsp;DPPH&nbsp;radical&nbsp;removal&nbsp;was&nbsp;calculated&nbsp;as&nbsp;46.8%,&nbsp;and&nbsp;the&nbsp;ascorbic&nbsp;acid&nbsp;equivalent&nbsp;was&nbsp;determined&nbsp;as&nbsp;35.5&nbsp;µM.&nbsp;The&nbsp;results&nbsp;demonstrated&nbsp;that&nbsp;Echinacea&nbsp;significantly&nbsp;accelerated&nbsp;wound&nbsp;healing&nbsp;due&nbsp;to&nbsp;its&nbsp;therapeutic&nbsp;and&nbsp;antioxidant&nbsp;properties.&nbsp;</p>

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