Efficiency of modulated and dose rate altered flattening filter free beams in high dose per fraction radiotherapy applications on the survival of prostate cancer cell lines
Articles > Article · 2021
Authors: C. Ceylan, A. Öztürk, G. Güngör, A.U. Karabey, S. Şahin, G. Duruksu, Y. Yazır, Güzide AKSU, Ö. Gündoğdu, Deparment of Biomedical Engineering, Kocaeli Univetsity, Kocaeli, Turkey
International Journal of Radiation Research, International, Scopus, 2021, vol 19, pp 879-889
Summary
Background:The radiobiological effect of high dose rate FFF beams on the DU-145 cells was investigated with SBRT plans which have >10 Gy.Methods and Materials: To compare the radiobiological effect on DU-145 cell line four experiments designed: (1) the constant dose rate of 6 MV and 6 MV FFF with increased dose per pulse (2) the effect of dose per pulse while increasing instantaneous dose rate for 6 MV and 6 MV FFF, (3) the effect of increased average dose rate for 6 MV FFF and (4) the effect of protracted treatment time and modulation of 6 MV FFF beams.The survival fraction was counted with WST.Results: FF and FFF for 6 MV with same dose rate and treatment time has no effect on cell survival.Significant differences was observed on survival which were irradiated with 6 MV 600 MU/min and 6 MV FFF 1400 MU/min (p=0.024).There was no difference between 6 MV FFF 600 MU/min and 6 MV FFF 1400 MU/min for 10 Gy.The significant survival difference obtained for 20 Gy.The survival percentages for both 10 Gy and 20 Gy with Cyberknife were obtained higher than FFF.Conclusion: Our in-vitro study presented here show that higher dose rate and reduced treatment time might become a crucial factor for SBRT especially which has >10 Gy fraction dose.