The synthesis and targeting of PPP-type copolymers to breast cancer cells: Multifunctional platforms for imaging and diagnosis
Makaleler > Tam Makale · 2012
Yazarlar: Demet Goen Colak, Ioan Cianga, Dilek ODACI, Özge KOZGUŞ GÜLDÜ, Emin İlker MEDİNE, Serhan Sakarya, Perihan Unak, Suna TİMUR, Yusuf Yağcı
JOURNAL OF MATERIALS CHEMISTRY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2012, cilt 22, ss 9293-9293
DOI: 10.1039/c2jm30692a
Özet
Herein, we demonstrate the synthesis and application of water-soluble, biomolecule conjugated PPP copolymers bearing poly(ethylene glycol) (PEG) side chains as fluorescent probes for the in vitro imaging of cancer cells. The targeting of fluorescent polymers to breast cancer cells allows effective visualization and discrimination of MCF7 cells from human mammary epithelial cells. Furthermore, these materials are also suitable for efficient radiolabeling via I-125 which enables dual-modality holding the possibility of both radioactive and fluorescence imaging in cancer diagnosis applications.