IgG-anti-IgA antibodies: An autoimmune finding in patients with psoriasis vulgaris
Articles > Article · 2012
Authors: Elif AZARSIZ, İlgen ERTAM SAĞDUYU, Neslihan KARACA, Güzide AKSU, S. Alper, Necil KÜTÜKÇÜLER
MINERVA MEDICA, Journal Indexed in SCI Expanded, International, Scopus, 2012, vol 103, pp 183-187
Summary
Aim. Psoriasis is thought to be an autoimmune disease caused by inappropriate activation of the cellular immune system. In this study, we aimed to search out IgG-anti-IgA antibody levels, serum immunoglobulins and antinuclear antibodies (ANA). Methods. The study entrolled 38 psoriasis vulgaris patients and 40 healthy controls. Results. Mean IgG-anti-IgA levels were significantly higher in psoriasis patients. The frequency of positive ANA testing was 21.1%; however, there was no correlation between IgG-anti-IgA antibody levels and ANA positivity. Only one patient had low IgA levels without high IgG-anti-IgA concentrations. Conclusion. The data about high IgG-anti-IgA antibody levels are noteworthy for a new evidence of autoimmune mechanism.