Investigation of radiolabelled chitosan nanoparticles bearing Cefpodoxime Proxetil, and in vitro antibacterial effect on Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli
Makaleler > Tam Makale · 2020
Yazarlar: Derya Ozel, Fatma YURT
Journal of Radioanalytical and Nuclear Chemistry, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2020, cilt 326, ss 1551-1558
DOI: 10.1007/s10967-020-07430-z
Özet
This study aims to investigate radiolabeled Cefpodoxime Proxetil loaded chitosan (CP-CS) nanoparticles as nuclear imaging infection agent to Gram-positiveStaphylococcus aureus(S. aureus) and Gram-negativeEscherichia coli(E. coli). The encapsulation efficiency of Cefpodoxime Proxetil was found 82 +/- 2%. CP and CP-CS nanoparticles were radiolabeled with Tc-99 m. The radiochemical purity of(99m)Tc-CP and(99m)Tc-CP-CS nanoparticles were determined by RTLC as 89 +/- 3% and 94 +/- 2% respectively. In vitro bindings of(99m)Tc-CP-CS nanoparticles toS. aureusandE. coliwere found higher than(99m)Tc-CP bindings.