New secondary metabolites from Gentiana spec.
Makaleler > Tam Makale · 2013
Yazarlar: D Kaya, FN Yalçın, E Bedir, TJ Schmidt, T Ersöz
Planta Medica, Uluslararası, Wos, 2013, cilt 79
Özet
The genus Gentiana (Gentianaceae) consists of many species with interesting phytochemical properties which have been widely used in traditional folk medicine [1]. Some members of Gentiana are used as folk remedies in Anatolia for their antipyretic, stomachic, stimulant of appetite, hepatoprotective, antidepressant and antidiabetic activities [2 – 5]. Iridoids, secoiridoids, C -glycosylflavones and xanthones are considered as the most promising groups of compounds responsible for the pharmacological activities of Gentiana species [1]. In a continuation of the phytochemical investigations on the genus, we have isolated one new flavonoid C -glucoside ( 1 ) along with 4 known compounds ( 2 – 5 ) from Gentiana pyrenaica and one new secoiridoid glucoside ( 6 ) and a known xanthone ( 7 ) from Gentiana verna subsp. pontica . The compounds were characterized by various chromatographic methods and the structures of the isolates were elucidated by means of spectroscopic ( 1 H-NMR, 13 C-NMR, 2D-NMR and Mass spectr.) evidence. Fig. 1 Acknowledgement: This work was supported by Hacettepe University Research Foundation (Project No. 0601301004). References: [1] Jensen S.R., Schripsema J. (2002) GENTIANACEA-Systematics and Natural History , Struwe, L., Albert, V. Eds., Cambridge University Press. [2] Baytop, T. (1999) Therapy with Medicinal Plants in Turkey (Past and Present), 2nd edn. Nobel Publication, İstanbul. [3] Ersöz, T., et al. (1991) Fitoterapia 62: 184 – 185. [4] Sezik, E., et al. (2005) Life Sci. 76: 1223 – 1238. [5] Deliorman, O.D., et al. (2003) Life Sci. 72: 2273 – 2283.