Investigation of in vitro Antileishmanial Activity of Moxifloxacin, Linezolid and Caspofungin on Leishmania tropica Promastigotes
Makaleler > Tam Makale · 2013
Yazarlar: Mine HOŞGÖR LİMONCU, Bayrı ERAÇ, Tugba GÜRPINAR, Ahmet ÖZBILGIN, I Cüneyt Balcioglu, Mine Hoşgör-Limoncu
Turkish Journal of Parasitology, Diğer Kurumların Hakemli Dergileri, Uluslararası, Scopus, 2013, cilt 37, ss 1-3
DOI: 10.5152/tpd.2013.01
Özet
OBJECTIVE: This study aimed to evaluate the potential in vitro anti-leishmanial activities of moxifloxacin, linezolid and caspofungin against Leishmania tropica. METHODS: In vitro effects of all agents were studied by using the microdilution method. For this purpose, serial dilutions of the aforementioned agents were prepared in concentrations between 4096 μg/mL-0.008 μg/mL. Afterwards, promastigotes incubated in suitable medium were counted with the hemocytometer and adjusted as having a last concentration of 2.5 x 10(6) cells/mL in wells containing medium+antibiotic or antifungal. After incubation live promastigotes were counted with the hemocytometer and inhibitor concentrations (IC(50)) were determined by comparing with the control that contained no antibiotics or antifungal. RESULTS: IC(50) values of moxiloxacin, linezolid and caspofungin were found as 194.7 μg/mL, 896 μg/mL and 235.7 μg/mL, respectively. CONCLUSION: As a result, moxifloxacin was found to be effective in lower concentrations than the other studied agents against L. tropica promastigotes.