Apoptosis-associated speck-like protein containing a CARD (ASC) expression profiles in familial Mediterranean fever (FMF) patients with different MEFV mutation patterns
Articles > Article · 2012
Authors: S NALBANTOGLU, Muhammed Bahattin TANYOLAÇ, Afig BERDELİ
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, Journal Indexed in SCI Expanded, International, 2012, vol 42, pp 159-162
DOI: 10.3109/03009742.2012.699551
Summary
Objectives: The inflammasome complex and the inflammatory pathway have been implicated in the pathogenesis of the most common autoinflammatory disorder, familial Mediterranean fever (FMF). Pyrin, the protein product of the FMF gene MEFV, interacts with the inflammasome complex adaptor protein ASC/PYCARD (apoptosis-associated speck-like protein with a CARD). Pyrin and ASC can both function as either inducers or suppressors of the cellular inflammatory response. We aimed to characterize ASC-induced gene expression profiles in FMF patients with different MEFV mutation patterns.